Overall, the colorectal cancer story is very encouraging. Incidence has dropped 46% since its peak and mortality has fallen 57%, thanks to colonoscopy screening, better treatment, and earlier detection. Indexed to 100 at 1995. Sources: NCI SEER*Stat, ACS CRC Facts & Figures 2023–2025, Siegel et al. CA Cancer J. Clin. (2023), Siegel et al. JAMA (2026).