Researchers at UC Berkeley and UC San Francisco have developed a CRISPR-based approach to selectively destroy cancer cells with a specific mutation in the p53 tumor suppressor gene. This method, called RNA-triggered chromatin shredding, can target "undruggable" cancers and potentially open up new targets for cancer therapy.
The user is concerned about the increasing number of contributions to their open source projects made with Large Language Models (LLMs), which they see as a threat to human involvement and interaction. They have implemented a new policy where they only accept contributions from real people, and reject those generated solely by LLMs, to maintain a more human-centered approach to coding.
Apple rewrote the TrueType hinting interpreter from C to memory-safe Swift to improve security and performance, achieving a 13% speed increase and exact compatibility with the C implementation. The Swift interpreter's design and optimizations, such as using noncopyable structures and Span, demonstrate the language's ability to balance safety, ergonomics, and performance, making it suitable ...
User upgraded Gemma 4 to MTP, achieving 72.2 tokens/second on an Apple M1 Max. MTP draft model improved performance by 24% with optimal settings found to be 3 draft tokens.
Malware developers added nuclear and biological text to spyware to evade AI security scanners. This highlights the need for balance between safety and functionality in AI models.
User trying to generate decent-looking programs with AI, found a "Qt style" trick that works for them, and wants feedback on its effectiveness and potential for other styles. They've successfully translated personal software to "Qt style" with AI tools like Codex.
Generate dashboards and analysis in BitBoard using AI chat or coding agents to create connected assets. Store connections, queries, and code for reproducible analysis and collaborate with teams in the browser.
A freelance translator in Ottawa prioritizes work over gym classes due to tight deadlines. She explains to a Director General that AI translation tools like ChatGPT are not a replacement for human translators, requiring constant coaching and double-checking.
Scientists have found that Earth's water may not have come from comets or asteroids, but rather from the planet's own processes. A new theory suggests that Earth's magma ocean and hydrogen-rich atmosphere could have combined to produce water.
A PDF can store both visual and structured data. By using a specific property in the PDF spec, a document can be created that renders visually the same but extracts clean markdown text when read by machines.
A free, offline-first stargazing web app — the live sky from where you stand, from naked-eye views down to a telescope eyepiece.
The user successfully booted a UEFI HTTP(S) setup using Qemu and OVMF, but encountered issues with certificate validation due to a security level mismatch. The problem was resolved by either upgrading the server's TLS certificate or patching the OVMF firmware to match the default security level.
Log in to the realm. Your characters live on the server and you share the world with everyone else who's on. Instant single-player world in your browser. Nothing is saved — perfect for a quick brawl or testing. WASD move · A/D turn, Q/E strafe · right-drag mouselook · left-drag orbit camera · wheel zoom · Space jump Tab target · 1-9,0 abilities · F interact/loot · C character · P ...
The author discusses the concept of "life before main" in Rust, where initialization happens before the main function is called, and explains how to use linker sections to register data and perform initialization in a single-threaded, highly-consistent environment. Linker sections allow for arbitrary aggregation and co-location of related data across the binary, and can be used to avoid ...
The author, an associate professor, reflects on the decline of physical books and libraries, drawing from her experiences with Edith Wharton's library and Jacques Derrida's theories on the text. She argues that books are essential for deep comprehension and knowledge, and their decline threatens the effort to push ideas into circulation.
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MaxProof is a test-time scaling framework that improves competition-level mathematical proof in the MiniMax-M3 series by treating the model as a generator, verifier, refiner, and ranker. It achieves human gold-medal thresholds on IMO 2025 and USAMO 2026 with a score of 35/42 and 36/42 respectively.
Right now, across the world, AI agents are repeating the same absurd act: to read one document, they each recompute it from scratch. Every agent re-runs prefill, the most compute-intensive step a large model takes, over identical text, only to rebuild a key-value (KV) cache identical to the one the agent before it just built. The same answer, computed a million times. We make a proposal that ...
Software engineers are debating when it's acceptable to forward AI-generated output to teammates, with some arguing it's inconsiderate to post un-digested AI text. Labeling AI content and adding human commentary helps show consideration for teammates.
StackScope analyses the tech stacks of new product launches. See what frameworks, hosting, analytics and tools sites use. Detect AI-built sites. Track technology trends.
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2026-06-12 13:19:29 UTC
ycombinator.com
Llama
Hazel is hiring a full stack engineer to deploy and scale AI for government procurement, requiring a TS/SCI clearance and experience with AWS, Python, and React. The role involves architecting and building Hazel's platform, working with customers, and delivering innovative solutions in a classified environment.
Law enforcement's "warrior mindset" prioritizes officer safety over community relationships, creating obstacles to improving police/community relations. A "guardian mindset" prioritizes service and community relationships, promoting public trust and officer safety through non-enforcement contacts and tactical restraint.
WASI 0.3 is now official, featuring native async support in WebAssembly Components. This simplifies async operations and enables better composability among components.
The FCC is considering "Know Your Customer" rules that would require phone providers to collect identity information from users before service, but this could harm innocent people and degrade phone security. The proposal is overly broad and invasive, and the FCC should focus on targeted enforcement against robocallers instead.
Apple has added a feature to macOS 26.5 allowing Macs to boot automatically when power is restored. This feature can be set to 'Always' boot, regardless of shutdown state, and is available on newer Macs.
Postgres 19 introduces native temporal table support with application-time tracking, allowing for overlap prevention and automatic row splitting during updates and deletes. This feature replaces the need for btree_gist and exclusion constraints.
MOST BEAUTIFUL WILL EVER MADE Written By One Who Died In Lunacy (By T.F.R.) Sir James Barrio, who presided at a recent dinner of the Authors' Club, at Grosvenor House, London, proposed “The Ladies and Literature,” but said that he had decided not to talk about love, or ladies, or literature, but about a will instead He said “In the days before the war, which is a new phrase for ‘Once upon ...
Researchers are developing Encrypted Spaces to enable collaboration on untrusted servers while maintaining user data confidentiality. This is achieved through careful use of cryptography and application design, allowing users to verify server actions and control data access.
Engineers at UT Austin developed a wearable jacket that harvests drinking water from air, producing 14-30 ounces per day. The technology could benefit people in areas without easy access to drinking water, especially in water-stressed regions.