Stanford researchers developed a new cancer therapy that tricks cancer cells into killing themselves by artificially combining two proteins. This approach, which uses the body's natural cell death process, aims to be more specific and effective than traditional treatments.
The author initially supported tools to track employee metrics but now believes they're unnecessary and can be counterproductive. They think managers should handle their team's performance, not rely on external tools or peer reviews.
Diagram as Code is a tool for prototyping and visualizing system architecture without design tools. It supports various cloud providers and frameworks, tracking changes in version control systems.
Gitpod spent 6 years trying to make Kubernetes work for development environments but found it too complex and security-challenged. They created Gitpod Flex, a new platform that simplifies development environment orchestration and prioritizes zero-trust security.
Quincy Jones, a renowned music producer and composer, has died at 91. He left a vast legacy in music, film, and television, collaborating with numerous artists including Michael Jackson and Frank Sinatra.
To keep security in mind when writing Go code, subscribe to the Go mailing list for critical security information and keep Go versions in projects current to ensure security patches and compatibility. Employ static code analysers like go vet, staticcheck, and golangci-lint to identify potential issues and vulnerabilities, and use tools like govulncheck and gosec to scan for known ...
The US Forest Service has stopped prescribed burning in California due to staff and equipment concerns, but state and tribal authorities have continued with their burns. This decision may undo mitigation work and increase wildfire risks in California.
Alonzo Church was a quiet logician who profoundly influenced Alan Turing's work and the development of the Turing Test. His λ-calculus and Church-Turing thesis laid the foundation for computer science and artificial intelligence.
The HTML to React/Figma extension by Magic Patterns allows users to convert web pages to editable React code or Figma designs with AI customization. It has a good record and is constantly updated with new features.
Supermarket executives use land use restrictions to monopolize rural markets by limiting competition. Companies like Albertsons impose restrictions on land to prevent new stores from opening, allowing them to maintain a monopoly and charge high prices.
META plans a new 16 fibre pair cable to connect the US East and West Coasts via the Atlantic, Indian Ocean, and Pacific, aiming for network resiliency. The cable will likely go from the US East Coast to Mumbai, then Singapore, with possible branches to Australia and Japan, and a direct line to the Californian coast.
Official site of graphic designer Paul Rand.
Large language models may retain unwanted knowledge after unlearning due to quantization. A new strategy is proposed to mitigate this issue by using quantization-robust unlearning.
The author is a developer who writes to share information, learn, and establish credibility. They recommend writing clearly, considering the audience and purpose, and finding a balance between personality and standardization.
The performance review process at big companies is often subjective and influenced by managers, who can use their power to make an employee's work seem good or bad. To avoid being a pawn in this process, it's best to focus on objective facts and avoid providing any information that could be used against a coworker in their performance review.
The author reflects on her experiences with technology, pregnancy, and loss, highlighting the importance of responsible use and human connection. She shares stories of her son Henry's birth and death, and her journey to cope with grief and find hope.
The word "just" in software engineering can imply simplicity and lead to missed complexities, causing engineers to be less likely to voice disagreement or ask for clarification. Stopping the use of "just" in statements can help foster a more open and collaborative environment where engineers feel more confident in sharing their ideas and understanding the solutions.
DB48X is a modern scientific calculator with RPL programming language, initially designed for SwissMicros DM32 and DM42 calculators. It also has an iPhone version and a browser-based demo.
FFmpeg developers achieved a 3-94 times performance improvement using handwritten AVX-512 assembly code. This optimization is ideal for compute-heavy tasks, particularly video and image processing, but is limited to AVX-512-capable hardware.
Robert Crumb, a renowned underground comics artist, created the iconic album cover for Janis Joplin and Big Brother and the Holding Company's Cheap Thrills, which became a symbol of the 1960s counterculture. Crumb's work on the album cover was a departure from his usual style, and he had little interest in the band's music, but he connected with Janis Joplin's love of old blues music.
GPUs are designed for massive parallelism and high throughput, with a focus on reducing instruction latency and increasing compute power. Their architecture consists of streaming multiprocessors, registers, shared memory, and global memory, which enable efficient execution of kernels and high occupancy rates.
Vogue is a triple-platinum hit by Madonna that topped charts worldwide and helped revive disco and house music. It features artificial stereophonic sound produced by QSound, a filtering algorithm that creates a 3-D soundscape.
The Q source hypothesis proposes a hypothetical written source, "Q," containing Jesus' sayings shared by Matthew and Luke but absent in Mark. Scholars believe Q existed due to similarities between Matthew and Luke, but its absence of narrative and lack of textual evidence make it a speculative theory.
DataChain is a Pythonic data-frame library for AI that organizes and wrangles data at scale. It integrates AI models and API calls into the postmodern data stack.
Scientists at UC Davis identified new cell clusters in the amygdala with differing gene expression patterns in humans and non-human primates. This discovery could lead to targeted treatments for anxiety and other disorders affecting tens of millions of people.
The author researched nutrient levels in retail grocery stores and found that speed of produce delivery is the only factor that matters for nutrient content, not price or organic certifications. Walmart consistently outperformed other retailers in terms of nutrient density due to its efficient supply chain.
Linux distributions have disabled frame pointer optimizations to allow profiling tools to produce stack traces without needing call-frame information. However, enabling frame pointers does not fully solve profiling issues due to limitations in unwinding and gaps in stack traces.
Researchers studied the DNA of Pando, a 16,000 to 80,000 year old quaking aspen tree in Utah, to understand its evolutionary history and adaptation. The study found surprising patterns of genetic variation and estimated the tree's age, suggesting it may have a mechanism to protect its genome from mutations.
Evolutionary algorithms are optimization algorithms that model the patterns of multi-generational evolution to find unique ideas by generating potential solutions and pitting them against each other in a process akin to natural selection. In this post, we used the petri_dish_lab gem to create a low-poly version of the Ruby logo using evolutionary algorithms, defining the objective, decision ...
Poor sleep in midlife may accelerate brain atrophy associated with dementia. Difficulty getting to sleep and early morning awakening are highly relevant to brain aging, especially when persistent over five years.
The Unix kernel interface for getting and setting terminal window size, TIOCGWINSZ, and the SIGWINCH signal were first introduced in 4.3 BSD in 1986. However, SIGWINCH was actually present in SunOS 0.4 from 1983, and TIOCGWINSZ may have been added earlier in SunOS source code.
Researchers created a cost-efficient radio telescope to detect 21 cm emissions and study neutral hydrogen in the Milky Way. The setup uses a 1-meter dish and can be used by amateurs to measure hydrogen cloud velocities and galaxy dynamics.
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Bloomberg delivers business and financial information worldwide. Grindr Inc is accused of violating labor law by enforcing a return-to-office policy to thwart unionization.
You worked on Manjaro Data Donor (MDD) to gather usage statistics and improve user counting. MDD aims to replace ping.manjaro.org with more accurate system identification.
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The NYT Tech Guild went on strike over wage increase and in-office expectations, with picketers demonstrating outside the NYT building. Perplexity's CEO offered to help the NYT with technical support during the strike, but his offer was met with criticism for potentially undermining the striking workers.
yt-dlp now requires Python 3.9 and its dependencies must be installed with the default group. Optional dependencies are included by default when installing yt-dlp[default].
The user used Amazon Q Developer to write Commodore 64 BASIC code that displays a sprite moving across the screen smoothly, and then converted it to 6502 assembler for faster performance. With Amazon Q's help, the user successfully created a sprite bouncing across the screen in Commodore 64 assembler, demonstrating the potential of Amazon Q Developer for modernizing legacy code.
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Engineer Dandridge Cole proposed the Aldebaran concept, a nuclear-powered launch vehicle that could carry 27,000 tonnes to low Earth orbit in the 1980s. The vehicle would use small nuclear devices to heat air, creating a hot and radioactive exhaust.
OpenWrt One is a device with WiFi 6, 1GB RAM, and 256 MiB NAND, with a failsafe recovery method for when it doesn't boot. It can be re-flashed using a TFTP server and mtk_uartboot binary after opening a serial console connection.
404 Media will co-publish two articles a month with WIRED, expanding its reach and audience. This partnership will not affect 404 Media's independence or subscriber benefits.
This project provides micro-implementations of historical programming languages in Python, including BASIC, Lisp 1.5, and APL. The implementations are concise, under 50 lines of code, and use only the Python standard library to serve as a learning resource.
The user added IPv6 to their OpenBSD home network using ifconfig, slaacd, dhcp6leased, rad, and unbound. They enabled IPv6 on both interfaces, set up DHCPv6 PD, and configured DNS for IPv6-only clients, successfully connecting to IPv6 websites.
A new Oxfam report reveals the world's richest 50 billionaires produce more carbon in 1.5 hours than the average person in their lifetime. Their emissions fuel inequality, hunger, and death, threatening the planet and its poorest communities.
The author wants to implement a feature called "Fold Method Bodies by Default" in various editors, which would automatically hide method bodies and show function signatures. This would improve code readability and is currently missing in many popular editors.
The NYT Tech Guild went on strike over wage increase and in-office expectations, with picketers demonstrating outside the NYT building. Perplexity's CEO offered to help the NYT with technical support during the strike, but his offer was met with criticism for potentially undermining the striking workers.
A ketogenic diet (KD) protects against experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, by altering the gut microbiota and increasing the production of the anti-inflammatory metabolite indole-3-lactate (ILA). The KD's protective effect is mediated by the gut microbiota, specifically by Lactobacillus species that produce ILA, which inhibits Th17 cells and reduces ...
US regulators backstopped Silicon Valley Bank's deposits, saving thousands of small tech startups but also helping bigger companies like Sequoia Capital and Kanzhun Ltd. The decision cost the US government's deposit insurance fund about $15.8 billion.
Developers still hardcode credentials into code despite best practices. CWE-79 and CWE-89 are top security weaknesses, including XSS and SQL injection.
Darl McBride, former SCO CEO, died on September 16, 2024, after a battle with ALS at 64. He was infamous for trying to sue Linux out of existence with SCO in the early 2000s.
IPv6 NAT is useful for handling complex network scenarios where devices have multiple internal networks. It allows devices to use a single IPv6 address on the main network and NATs traffic from their internal networks.
Large institutional investors like Blackstone are buying up housing, making it less affordable, but their impact is minor due to their small fraction of single-family homes. However, their entry has led to increased housing supply and lower costs, benefiting renters but also giving them market power, which affects house prices.
A place to share and showcase your 3D captures
Birmingham City Council's Oracle implementation disaster is estimated to cost £216.5 million by April 2026 due to failed savings and increased spending. The council's inability to file auditable accounts and detect fraud led to a public inquiry call and criticism of senior management's handling of the issue.
Wi-Fi 8 prioritizes ultra high reliability over extremely high throughput. It aims to improve wireless communication by focusing on reliability.
The software industry lacks a reliable way to measure productivity due to the difficulty in measuring output, with methods like lines of code and function points being flawed. True productivity should be based on delivered business value, not just functionality or lines of code.
The author visits the Bob Dylan Center in Tulsa, Oklahoma, and explores the exhibits and archives, including handwritten manuscripts and rare artifacts. The Center houses the Bob Dylan Archive, which contains over 100,000 items, including tour posters, fan letters, and original handwritten manuscripts.
Mem0 allows seamless context sharing across AI assistants like ChatGPT and Claude. It's a free Chrome extension requiring an API key from the Mem0 Dashboard.
John Calhoun, a psychologist, studied overcrowding in mice and rats, predicting human population problems. His work, though influential in popular culture, has largely been forgotten in academic circles due to methodological and linguistic criticisms.
The user moved their website from Netlify to a Linux server running Caddy due to high bandwidth costs and limited flexibility. They achieved a smooth migration with minimal downtime and now have a more cost-effective and predictable hosting solution.
The Local Peer-to-Peer API allows browsers to communicate directly without a server in between, enabling local communication use-cases. It aims to provide a seamless, secure, and privacy-preserving experience for users.
A 39-year-old executive, Vera Wang, lost her job at Vogue and started a business designing dresses, becoming one of the most successful fashion designers with a net worth of over $650 million. Research shows that starting a business can reduce stress, improve health, and increase financial stability, debunking myths that keep employees from healthier and more satisfying lives.
Ralph Abraham was a renowned mathematician and counterculture figure who died at 88, leaving behind a legacy of groundbreaking work in chaos theory and field dynamical systems. He was a curious and open-minded individual who explored various interests, including psychedelics, Eastern mysticism, and electronica music.
User is describing various landscapes to upload to Oasis, a beta platform for adventure scenes. The user is showcasing serene and natural environments for exploration.
XENON is a notation for defining objects, arrays, and scalars in a network/graph structure. It supports various data types, including booleans, integers, real numbers, dates, and timestamps, and allows for comments, escaping, and referencing entities.
Researchers at Tepper School of Business studied how large language models (LLMs) impact collective intelligence, highlighting both benefits and risks. LLMs can enhance group collaboration but require careful consideration to maintain diversity and avoid pitfalls.
this is so absurd it's crazy lmfao 2x 16GBx256GB mac minis cost 1$ cheaper than a single 32GBx512GB mac mini
The Gemini protocol is a clean and minimal alternative to the World Wide Web, created by Solderpunk in 2019 to provide a focused and private browsing experience. It uses the existing Internet Protocol Stack but creates an orthogonal Application at the application layer, and can be deployed on a server using a language like Lua or by using an existing server solution like gmid.
Examples
Hans Reiser, a brilliant software developer, created a revolutionary Linux filesystem, but his difficult personality and ambition led to a tragic downfall, including a murder conviction for his wife's disappearance. His legacy serves as a cautionary tale about the importance of empathy and collaboration in the tech world.
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Germany's labor market is experiencing a negative trend with companies more likely to lay off employees than fill vacancies. The ifo Employment Barometer fell to 93.7 points in October, its lowest level since July 2020.
The author is grateful to Princess Kate for sharing her cancer story, which helped them cope with their own diagnosis. The author is now speaking out about their own cancer experience to raise awareness and pay it forward, but also to discuss how reproductive freedom and innovation are under attack in America.
The USB Insight Hub is a USB 3.0 hub with three downstream ports, each with a 1.3-inch screen displaying device information, and allows for individual power and data control. It features over-current and back-current protection, a global power button, and is open hardware with readily available drivers and work-in-progress property-extraction software.
Executives are rethinking work-from-home policies to boost profits by reducing turnover and recruiting costs. A hybrid work model with performance management and support from leadership can increase employee satisfaction and save millions.
A new poll found nearly half of Americans think members of the opposing party are 'evil'. Three-quarters of Republicans who believe Trump won the 2020 election agree with this sentiment.
The Unicode Standard includes characters with case distinction that are not uppercase or lowercase, such as the Latin Small Letter DZ. This character is special because it's used in Serbo-Croatian for one-to-one transliteration between Latin and Cyrillic scripts.
The Carnian Pluvial Event, a 232 million-year-old climate shift, brought intense rainfall to Earth, lasting one to two million years and altering life on the planet. A massive volcanic eruption triggered this event, causing rapid climate change, mass extinctions, and paving the way for new life forms to emerge.
Sam Raskin and his team solved a segment of the Langlands Conjectures, a decades-old math problem. Their proof could lead to translating areas of math and has implications for physics, including particle physics and electricity and magnetism.
AWK is a scripting language for text processing, consisting of patterns and actions, with an implied loop that reads and parses each record of a file. It has built-in functions for arithmetic, string manipulation, and input/output operations.
A giant ASCII boob art remained in a codebase due to fear of admitting past mistakes. New blood can shake up the status quo by addressing long-ignored problems.