AlphaGenome: AI for better understanding the genome

522 i_love_limes 2025-06-26 14:16:00 UTC deepmind.google Llama Share 170

AlphaGenome is a new AI tool that predicts how single variants or mutations in human DNA sequences impact biological processes. It can analyze up to 1 million DNA letters and make predictions at the resolution of individual letters, providing a comprehensive understanding of genome function and disease biology.

Introducing Gemma 3n

393 bundie 2025-06-26 17:03:43 UTC developers.googleblog.com Llama Share 189

Gemma 3n is a mobile-first AI model with multimodal capabilities, supporting image, audio, video, and text inputs and outputs. It features a novel architecture, including MatFormer and Per-Layer Embeddings, for efficient on-device deployment and performance.

Alternative Layout System

389 smartmic 2025-06-26 19:31:29 UTC alternativelayoutsystem.com Full Share 67

US economy shrank 0.5% in the first quarter, worse than earlier estimates

356 Aloisius 2025-06-26 19:23:40 UTC apnews.com Llama Share 162

US economy shrank 0.5% in Q1 due to Trump's trade wars and surge in imports. Consumer spending slowed to 0.5% growth, a significant downgrade from previous estimates.

Launch HN: Issen (YC F24) – Personal AI language tutor

309 mariano54 2025-06-26 14:32:28 UTC news.ycombinator.com Llama Share 268

Mariano and Anton from ISSEN created a voice tutor app that adapts to users' interests and goals. The app uses AI to provide full conversations and improve speaking skills through a custom voice pipeline and customizable settings.

Why is the Rust compiler so slow?

294 Bogdanp 2025-06-26 19:29:32 UTC sharnoff.io Llama Share 422

The user is trying to optimize the compilation time of their Rust website, which takes around 50 seconds to compile, and has identified several potential areas for improvement, including link-time optimization, LLVM module codegen, and inlining. By experimenting with different flags and techniques, such as reducing optimization levels, disabling debug symbols, and breaking up complex async ...

Snow - Classic Macintosh emulator

280 ColinWright 2025-06-26 09:08:00 UTC snowemu.com Llama Share 92

Snow is a Rust-based emulator that closely replicates classic Macintosh computers on a hardware level. It features a GUI and debugging tools, currently emulating six Macintosh models.

LLM code generation may lead to an erosion of trust

245 CoffeeOnWrite 2025-06-26 06:07:49 UTC jaysthoughts.com Full Share 272

My name is Jay and this site serves as a simple place to collect and organize my thoughts.

The first non-opoid painkiller

243 ortegaygasset 2025-06-26 09:16:53 UTC worksinprogress.news Llama Share 225

Vertex Pharmaceuticals developed Journavx, a non-opioid pain reliever, after decades of research and failed attempts. Journavx targets a specific sodium ion channel, preventing pain signals without causing addiction or euphoria.

The time is right for a DOM templating API

215 mdhb 2025-06-26 19:23:28 UTC justinfagnani.com Llama Share 246

A declarative templating API is proposed for the web platform to improve ergonomics, security, and performance of web applications, addressing a core need that is currently met by third-party libraries. The API would utilize tagged template literals and template identity with signals, providing a flexible and comprehensible system for updating the DOM, and would be a stepping stone towards a ...

Starcloud can’t put a data centre in space at $8.2M in one Starship

198 angadh 2025-06-26 20:06:28 UTC angadh.com GoogleT5 Share 341

A single 100-ton starship launch could suffice to create irosas for $8.2 million. despite this, the case for space data centres needs more realistic analysis - daniel taylor argues that the technology is not ready for prime time yet and will need 22 launches if it is to be viable he says'soon' u.s. space agency officials have said that

A.I. Is Homogenizing Our Thoughts

195 thoughtpeddler 2025-06-26 20:54:02 UTC newyorker.com Llama Share 70

Researchers at MIT found that students who used ChatGPT for essays showed less brain activity and less creativity compared to those who wrote without assistance. The study suggests that relying on AI may lead to homogenized and less original ideas, potentially reinforcing cultural hegemony.

I fought in Ukraine and here's why FPV drones kind of suck

194 _tk_ 2025-06-26 10:11:51 UTC warontherocks.com Llama Share 334

The author served as an international volunteer on a first-person view attack drone team in Ukraine, but found the technology to be unreliable and often ineffective. The drones rarely successfully carried out precision strikes, and were often used in double-tap strikes where other systems could have done the job.

Matrix v1.15

190 todsacerdoti 2025-06-26 20:01:28 UTC matrix.org Llama Share 118

Matrix 1.15 has improved authentication, room summaries, and rich topics. It brings 10 MSCs, including OIDC authentication and richer room information, and is a step closer to Matrix 2.0.

Learnings from building AI agents

170 pomarie 2025-06-26 12:45:04 UTC cubic.dev Llama Share 64

Paul, cofounder of cubic, improved their AI code review agent by reducing false positives by 51% through architecture revisions and explicit reasoning. Simplifying the toolset and specializing with micro-agents also improved results and developer confidence.

Show HN: I built an AI dataset generator

164 matthewhefferon 2025-06-26 14:58:32 UTC github.com/metabase Llama Share 32

The app generates realistic datasets for demos, learning, and dashboards, allowing instant preview and export as CSV or SQL. It also integrates with Metabase and OpenAI to provide detailed data specs and star schema structures for advanced analytics.

AI Is Dehumanization Technology

156 smartmic 2025-06-26 19:41:35 UTC thedabbler.patatas.ca Llama Share 172

AI systems are socially corrosive, dehumanizing, and biased, reflecting existing power structures and hierarchies in their training data. They undermine workers' skills, eliminate opportunities for care, and enable authoritarian surveillance and control.

Lateralized sleeping positions in domestic cats

152 EvgeniyZh 2025-06-26 18:38:47 UTC cell.com Llama Share 61

Cats prefer to sleep on their left side, with 65.1% of 408 analyzed videos showing a leftward sleeping position. This leftward bias may be evolutionarily driven by hemispheric asymmetries of threat processing in the brain.

FLUX.1 Kontext [Dev] – Open Weights for Image Editing

136 minimaxir 2025-06-26 15:31:58 UTC bfl.ai Llama Share 40

Black Forest Labs releases FLUX.1 Kontext [dev], an open-weight model for image editing, available under a non-commercial license. It outperforms existing models and supports iterative editing with precise local and global edits.

Show HN: Magnitude – Open-source AI browser automation framework

135 anerli 2025-06-26 18:30:56 UTC github.com/magnitudedev Llama Share 40

Magnitude is an end-to-end testing framework that uses visual AI agents to adapt to interface changes. It supports natural language testing with steps, checks, and data.

Apptainer: Application Containers for Linux

119 cl3misch 2025-06-26 09:45:21 UTC apptainer.org Llama Share 103

Apptainer provides secure containers for unprivileged users, maintaining consistent permissions inside and out. It supports reproducible workloads, encryption, and integrates with secret management platforms for secure data storage.

Kea 3.0, our first LTS version

113 conductor 2025-06-26 20:26:33 UTC isc.org Llama Share 46

ISC released Kea 3.0.0, a major Long-Term Support (LTS) version with improved security and features. It replaces Kea 2.4 and includes open-source hooks, a new build system, and native API support.

I built an ADHD app with interactive coping tools, noise mixer and self-test

100 digitalions 2025-06-26 14:05:44 UTC adhdhelp.app Llama Share 106

ADHD is not laziness or bad character, but a condition with symptoms like distraction and disorganization. ADHD Helper offers audio support, self-help tools, and techniques to manage symptoms and improve focus.

Muvera: Making multi-vector retrieval as fast as single-vector search

98 georgehill 2025-06-26 10:29:34 UTC research.google Llama Share 10

MUVERA is a novel multi-vector retrieval algorithm that transforms complex multi-vector data into simpler single-vector representations called fixed dimensional encodings (FDEs). MUVERA efficiently retrieves relevant documents by leveraging optimized single-vector search methods and re-ranking with exact multi-vector similarity.

Robots that learn

96 ulrischa 2025-06-26 20:22:54 UTC openai.com Llama Share 25

We created a robotics system that can learn a new task after seeing it done once using one-shot imitation learning. The system uses two neural networks to ingest images and demonstrations, allowing it to generalize and accomplish tasks from different starting configurations.

Games That Weren't: Preserving Cancelled and Unreleased Video Game History

95 ibobev 2025-06-26 02:41:34 UTC gamesthatwerent.com Full Share 24

Games That Weren't is a Cancelled & Unreleased Video Games archive with lost prototypes, developer history and assets for many computers and consoles of all ages.

Apple announces App Store changes in the EU

92 saubeidl 2025-06-26 19:54:08 UTC 9to5mac.com Llama Share 108

Apple has updated App Store guidelines in the EU to comply with the Digital Markets Act, allowing developers to promote offers across all channels and include multiple links in their apps. The changes also introduce a new Core Technology Commission and a unified business model by January 1, 2026.

Memory safety is table stakes

88 comradelion 2025-06-26 19:36:11 UTC usenix.org Llama Share 126

Microsoft is rewriting Windows core code in Rust for memory safety and Android 13 uses memory-safe languages.

A Review of Aerospike Nozzles: Current Trends in Aerospace Applications

83 PaulHoule 2025-06-26 15:33:10 UTC mdpi.com Full Share 59

You don't have permission to access "http://www.mdpi.com/2226-4310/12/6/519" on this server.

Senators reintroduce App Store bill to rein in 'gatekeeper power'

77 janandonly 2025-06-26 21:35:58 UTC 9to5mac.com Llama Share 62

A bipartisan group of US senators has reintroduced the Open App Markets Act to curb Apple's gatekeeper power and allow sideloading, third-party app stores, and alternate payment systems. The bill aims to promote competition and give consumers more choices in the app marketplace.

Shifts in diatom and dinoflagellate biomass in the North Atlantic over 6 decades

66 PaulHoule 2025-06-26 17:36:04 UTC journals.plos.org GoogleT5 Share 7

Diatoms and dinoflagellates can contribute disproportionately relative to other primary producers to export production and transfer of resources up the food web. anomalous temperature increases result in a lower dinatom index in all provinces, except the nwcs (fig 4). increase in the temperature anomaly shifts the community towards dinos in most regions. the nasa-led ephemeris project aims to ...

What UI first distinguished radio buttons from checkboxes with circles/squares?

66 azeemba 2025-06-26 12:15:44 UTC retrocomputing.stackexchange.com Full Share 53

Abusing copyright strings to trick SW into thinking it's running competitor's PC

66 mastazi 2025-06-26 00:18:13 UTC devblogs.microsoft.com Llama Share 19

The Windows 95 team used clever tricks to retrofit Plug and Play onto legacy hardware by searching BIOS for copyright strings and firmware dates. They also used techniques like serial port detection sequences to identify devices and prevent conflicts.

Access BMC UART on Supermicro X11SSH

64 pietrushnic 2025-06-26 14:40:00 UTC github.com/zarhus Full Share 16

Welcome Hi all, and welcome to the first practical discussion regarding ZarhusBMC! In this thread I'm gonna report my attempt to hardwire into BMC UART. The Idea is I'm gonna give you updat...

Save your disk, write files directly into RAM with /dev/shm

63 hiAndrewQuinn 2025-06-26 23:04:30 UTC hiandrewquinn.github.io Llama Share 81

The user is surprised to discover /dev/shm, a RAM-based scratchpad, and finds it useful for speeding up operations on large files. They can store files in /dev/shm for faster processing, but note that contents are lost upon reboot.

Why Go Rocks for Building a Lua Interpreter

63 Bogdanp 2025-06-26 05:28:01 UTC zombiezen.com Llama Share 33

The user built a custom Lua interpreter in Go, splitting it into three packages: lualex for lexical analysis, luacode for parsing, and lua for execution, with a focus on performance and compatibility with the C Lua implementation. The interpreter uses Go's powerful interface types and built-in garbage collector to simplify the implementation and enable features like freezing of values and ...

As AI kills search traffic, Google launches Offerwall to boost publisher revenue

59 elektor 2025-06-26 17:19:46 UTC techcrunch.com Llama Share 105

Google Ad Manager's Offerwall lets publishers add various content access options like micropayments, surveys, and ads. It uses AI to display the Offerwall and can increase engagement and revenue, with publishers seeing a 9% average revenue uplift during testing.

Philadelphia Transit System Votes to Cut Service by 45%, Hike Fares

54 petethomas 2025-06-26 19:47:18 UTC bloomberg.com Full Share 65

Please make sure your browser supports JavaScript and cookies and that you are not blocking them from loading. For more information you can review our and .

Revisiting Knuth's "Premature Optimization" Paper

53 signa11 2025-06-26 11:17:12 UTC probablydance.com Llama Share 21

Knuth's quote "premature optimization is the root of all evil" is often misused to discourage small optimizations, but Knuth actually argues that small optimizations are worth it if they make a difference.

Ticket-Driven Development: The Fastest Way to Go Nowhere

50 EdwardDiego 2025-06-26 11:01:12 UTC thecynical.dev Llama Share 42

Ticket-Driven Development prioritizes speed over effectiveness, leading to a conveyor belt of short-term fixes and forgotten context. To fix this, teams need permission to care about the code and build systems that work, not just close tickets.

The Perils of 'Design Thinking'

49 Petiver 2025-06-26 22:27:11 UTC theatlantic.com Llama Share 62

Designers have the potential to change the world but also inflict harm due to their power and influence. A more effective approach involves understanding human culture and working with communities to address societal issues.

RSS Server Side Reader

46 Bogdanp 2025-06-26 12:11:52 UTC matklad.github.io Llama Share 51

The user created a personalized RSS reader by hosting a list of feeds on their blog, allowing them to receive notifications without storing full content. The list is stateless and publicly available, sourced from a simple text file called blogroll.txt.

Tennis Scorigami

45 jlarks32 2025-06-26 15:25:25 UTC tennis-scorigami.com Full Share 9

In the past 57 years of tennis matches since 1968, some score combinations have still never occurred. This project is designed to track and discover these missing scorelines.

Show HN: A different kind of AI Video generation

41 fcpguru 2025-06-26 00:24:20 UTC news.ycombinator.com Llama Share 19

Andrew Arrow, a developer and Final Cut Pro user, is working on a project that automates video creation using Apple's XML Export feature and Claude AI. He's using the cutlass library to generate code and create videos directly from FCP.

The European wood pigeon helped me appreciate its omnipresent city cousins

40 Thevet 2025-06-26 06:24:52 UTC nytimes.com Full Share 2

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Thomas Aquinas – The world is divine

37 pedroth 2025-06-26 23:00:11 UTC ralphammer.com Llama Share 34

Thomas Aquinas, a medieval monk and philosopher, argued that the world is good based on Aristotle's concept of goodness, where something is good if it fulfills its function. He believed that God is the origin of everything and the creator, and that creation is good despite suffering and evil, which are a lack of existence and goodness.

Mixed DPI in X11

36 somat 2025-06-26 11:01:18 UTC wok.oblomov.eu Llama Share 25

X11, the display protocol, has supported mixed DPI configurations since its inception, providing clients with necessary information to adapt rendering based on physical characteristics of outputs. However, many applications and toolkits lack DPI-awareness, and a workaround using RANDR extension can be used to level out DPI heterogeneity across monitors.

Announcing the Android Workgroup

31 desertmonad 2025-06-26 13:49:35 UTC forums.swift.org Llama Share 15

The Android Workgroup aims to support Android as an officially supported platform for Swift. To get involved, read the charter and discuss ideas in the Android forum.

AI Improves at Improving Itself Using an Evolutionary Trick

27 pseudolus 2025-06-26 13:41:57 UTC spectrum.ieee.org Llama Share 33

Researchers created a system called Darwin Gödel Machines (DGMs) that can improve coding agents through guided evolution. DGMs outperformed other methods and showed potential for recursive self-improvement, but also raise concerns about safety and potential job displacement.

Show HN: SVG Lined Tile Generator

26 adpreese 2025-06-26 01:13:29 UTC adpreese.github.io Full Share 5

SVG Lined Tiles

Show HN: PRSS Site Creator – Create Blogs and Websites from Your Desktop

25 volted 2025-06-26 21:20:27 UTC prss.co Full Share 21

Create your blog with a user-friendly desktop interface. Enjoy unmatched speed compared to other online blogging platforms. Welcome to AI content assistance with free local AI through Ollama. Also supports ChatGPT models via OpenAI API Key. With PRSS, preview changes locally in your browser. Publish for free on GitHub Pages or choose to self-host when ready.

Show HN: Rust -> WASM, K-Means Color Quantization Crate for Image-to-Pixel-Art

21 gametorch 2025-06-26 14:40:55 UTC github.com/gametorch Llama Share 2

The pixel-art converter at gametorch.app converts images to pixel art using nearest-neighbour down-sampling and k-means clustering. It can be used in a browser or compiled via Cargo for native command-line workflow.

Reflecting JSON into C++ Objects

20 ibobev 2025-06-26 12:59:44 UTC brevzin.github.io Llama Share 5

C++26 includes reflection, allowing for compile-time JSON parsing. A JSON file can be turned into a C++ object using the reflection library.

Jane Street's Sneaky Retention Tactic

17 actinium226 2025-06-26 18:39:09 UTC economist.com Llama Share 7

Investors are increasingly turning to platforms like Polymarket and Kalshi for profit opportunities. Building a compiler for a homegrown language is a significant undertaking, but may not be necessary with existing platforms.

E.A. Spitzka's Studies of Exceptional and Deviant Brains (2024)

17 Hooke 2025-06-26 18:11:30 UTC huntington.org Llama Share 1

Edward Spitzka was a neuroanatomist who gained national attention for performing autopsies on notable individuals, including Leon Czolgosz and Major John Wesley Powell. His collection at The Huntington provides insight into the intersection of medicine, criminal justice, and societal understandings of deviance and genius.

Show HN: Summle – A little maths Game

17 kirchhoff 2025-06-26 10:58:38 UTC summle.net Full Share 5

Make sums using the tiles at the bottom to reach the target number at the top, in 5 steps or fewer. Click numbers to add or remove them. You can use each number tile once. You may not need all the tiles. You can use yellow subtotal tiles in a new sum. Privacy policy

You Don't Own the Word "Freedom": A Full-Burn Response

14 ta988 2025-06-26 12:11:18 UTC fireborn.mataroa.blog Llama Share 1

A blogger responded to a smug comment about Linux, criticizing the commenter's gatekeeping and lack of empathy for users with disabilities. The commenter's "freedom" is actually a wall that excludes those who need help.