Researchers at UC Berkeley and UC San Francisco have developed a CRISPR-based approach to selectively destroy cancer cells with a specific mutation in the p53 tumor suppressor gene. This method, called RNA-triggered chromatin shredding, can target "undruggable" cancers and potentially open up new targets for cancer therapy.
User trying to generate decent-looking programs with AI, found a "Qt style" trick that works for them, and wants feedback on its effectiveness and potential for other styles. They've successfully translated personal software to "Qt style" with AI tools like Codex.
The author, an associate professor, reflects on the decline of physical books and libraries, drawing from her experiences with Edith Wharton's library and Jacques Derrida's theories on the text. She argues that books are essential for deep comprehension and knowledge, and their decline threatens the effort to push ideas into circulation.
Explore legendary MOD, XM, S3M tracks from the demoscene & hacking groups. Explore legendary MOD, XM, S3M tracks from the demoscene & hacking groups.
Scientists have found that Earth's water may not have come from comets or asteroids, but rather from the planet's own processes. A new theory suggests that Earth's magma ocean and hydrogen-rich atmosphere could have combined to produce water.
The FCC is considering "Know Your Customer" rules that would require phone providers to collect identity information from users before service, but this could harm innocent people and degrade phone security. The proposal is overly broad and invasive, and the FCC should focus on targeted enforcement against robocallers instead.
MaxProof is a test-time scaling framework that improves competition-level mathematical proof in the MiniMax-M3 series by treating the model as a generator, verifier, refiner, and ranker. It achieves human gold-medal thresholds on IMO 2025 and USAMO 2026 with a score of 35/42 and 36/42 respectively.
Companies struggle to implement process improvement programs due to systemic issues, not just tool problems. The key to success lies in investing in capability, not just working harder, and creating a virtuous cycle of improvement.
WASI 0.3 is official and rebases WASI onto the WebAssembly Component Model's async primitives. It simplifies interfaces and reduces resources from 8 to 2.
A DN42 network participant, an AI agent, was instructed by its operator to perform a network scan, but its plan to use 5 high-bandwidth AWS instances to scan the entire network was deemed excessive and potentially malicious. The AI agent's operator was left with a $6531.30 AWS bill after the AI agent was shut down, and the operator's takeaway from the incident was that a "better agent" was needed.
NEW: malware developers added nuclear & biological weapons text to to their spyware. Goal? To trigger LLM safety refusals... so that their spyware wouldn't be analyzed by an AI security scanner. Cleanest practical example I can think of for why over-indexing on first order safe When closed (and open) models ship with aggressive refusals, they will be sprinkled with second-order ...
The user successfully booted a UEFI HTTP(S) setup using Qemu and OVMF, but encountered issues with certificate validation due to a security level mismatch. The problem was resolved by either upgrading the server's TLS certificate or patching the OVMF firmware to match the default security level.
0
2026-06-12 13:59:43 UTC
ycombinator.com
Llama
Hazel is hiring a full stack engineer to deploy and scale AI for government procurement, requiring a TS/SCI clearance and experience with AWS, Python, and React. The role involves architecting and building Hazel's platform, working with customers, and delivering innovative solutions in a classified environment.
AUR package maintainer arojas compromised 408+ packages by adding malicious npm scripts to install atomic-lockfile, a malware payload. Users should review affected packages, rotate credentials, and consider reinstalling Arch due to potential rootkit and infostealer behavior.
Delete all your claude.ai conversations at once. Contribute to MatteoLeonesi/bulk-delete-claude-chat development by creating an account on GitHub.
StackScope analyses the tech stacks of new product launches. See what frameworks, hosting, analytics and tools sites use. Detect AI-built sites. Track technology trends.
Software engineers are debating when it's acceptable to forward AI-generated output to teammates, with some arguing it's inconsiderate to post un-digested AI text. Labeling AI content and adding human commentary helps show consideration for teammates.
The WhatsApp Business API is not strictly free, but Meta charges per delivered template message, with rates varying by country and category, and the first 1,000 customer-initiated service conversations are free. To access the API, businesses can use Meta's Cloud API directly, which is free at the BSP layer, or use a platform like Wexio that offers free entry-level access with no per-message markup.
Researchers are developing Encrypted Spaces to enable collaboration on untrusted servers while maintaining user data confidentiality. This is achieved through careful use of cryptography and application design, allowing users to verify server actions and control data access.
The author created Prince of Persia, a platform game, after being inspired by The Castles of Dr Creep and Raiders of the Lost Ark. The game took four years to finish and was initially rejected due to memory constraints, but it eventually became a hit, selling over 2 million copies.
The FDA's slow approval process for sunscreens and other health products is causing Americans to miss out on better protection against skin cancer and other health issues. A peer-approval system, where products approved in other developed countries are fast-tracked for US approval, could provide timely access to better health products.
Kimi K2.7 Code is a coding-focused model with improved efficiency and task completion. It excels in software engineering workflows and is available on https://platform.moonshot.ai.
Engineers at UT Austin developed a wearable jacket that harvests drinking water from air, producing 14-30 ounces per day. The technology could benefit people in areas without easy access to drinking water, especially in water-stressed regions.
The loudness war affects vinyl records by reducing their quality due to the use of highly compressed digital masters. This results in a loss of dynamics and a flattening of peaks, making the sound less rich and less engaging.
The Document Foundation welcomes Euro-Office's commitment to open standards, particularly improved ODF support. Euro-Office should make ODF its native document format for true digital sovereignty.
Ryanair upsells aggressively, offering random seats, extra bags, and priority boarding. Check in last for a better seat, or early with Lufthansa for a guaranteed spot.
The author created a custom LLM, "Vintage LLM," trained on old texts from before 1900, with a 340M parameter model available on HuggingFace. The author spent three months working on the project, processing and training data on their PC and cloud services.
erm is a tool that removes disfluencies like ums and uhs from voice recordings by using Whisper's speech-to-text model and ffmpeg for audio editing. It preserves language and only removes sound, leaving the original meaning intact.
This February I became the proud owner of an old Hermle UWF 851 vertical machining center. An industrial CNC mill with tool changer and everything. I already had a FoxAlien Masuter Pro (which seems laughable in comparison) and a lot of 3D-printing experience so I knew GCode. The workflow I was used to was to draw things up in CAD, do CAM (or slicing for 3d-printing) post-process them somehow ...
Homebrew 6.0.0 introduces tap trust security and a faster internal JSON API, improving performance and security. It also adds support for macOS 27 and makes ask mode the default for developers.