Researchers found that adding an experimental drug, bepirovirsen, to standard antivirals cured 19% of people with hepatitis B virus in two trials. The results are promising but may not be effective for the majority of the 240 million people worldwide living with chronic HBV infections.
The APC-2 is a professional record cutter with superior sound quality, available exclusively through SUPERSENSE. It features advanced technology for precision cutting and control.
The author of Have I Been Pwned reflects on the 1,000th breach loaded into the database, questioning its continued purpose due to emerging privacy regulations. Disclosure lag times for breaches are worsening, with companies taking months to notify victims.
A perceptron is a simple neural network that takes one input, weighs it with a weight, adds a bias, and decides with a yes-or-no answer, and it learns from its mistakes by adjusting the weight and bias. The perceptron's ability to learn and make decisions relies on the weight, bias, learning rate, and normalization of the input data, which can be adjusted to improve its accuracy and performance.
The user spent 14-16 years in juvenile prison and later became a convicted felon due to addiction, but rebuilt their life through software and open-source contributions. They now work at Hasura, a developer-facing tool, and hope to give others a chance despite their troubled past.
You coined the term "dopamine fracking" to describe the harm caused by prioritizing short-term dopamine hits over long-term cultural and personal sustainability. This phenomenon erases complexity and nuance, replacing it with a homogenized, commodified culture devoid of meaning and connection.
DeepSeek V4 Pro wins this head-to-head by being more exact where it matters: following instructions, matching schemas, and solving edge cases cleanly. GPT-5.5 Pro is still strong, but it gave away points with avoidable deviations.
Employers rely heavily on hiring algorithms, but a study of 3.4 million job applicants found large-scale racial disparities and homogeneous outcomes. Algorithmic monocultures in hiring yield systemic rejections, with 25.87% of Black and 14.74% of Asian applicants facing adverse impact.
The One World Flag represents unity and a shared home for all inhabitants of the blue planet. It symbolizes that more unites us than divides us, promoting a sense of belonging and togetherness.
The author created a pancake calculator to optimize pancake recipes by balancing four axes of quality: interior texture, tang, rise, and exterior crisp. The calculator uses stoichiometry to determine the optimal ratio of ingredients, including acid, leavening agents, and dairy, to create the perfect pancake.
NoSuggest is a free YouTube app with no ads, no notifications, and no algorithm-driven recommendations. It allows users to add and watch specific channels on their devices without any external influence.
This repository contains Rust examples for the Raspberry Pi Pico 2 using Embassy async framework, including sensors and displays. Examples include ADXL345 accelerometer, DS18B20 temperature sensor, DHT11 temperature and humidity sensor, and more.
The gcc libstdc++ algorithm and the forward-iterator algorithm are the same, but with different perspectives. The new algorithm is symmetric and performs swaps from right to left if the larger block is on the right.
This project implements an autoregressive sequence model using a transformer architecture. The model processes sequences of bytes (8-bit tokens), learning to predict the next byte given previous context. While this implementation trains on text data, the architecture is agnostic to the content. It can model any byte stream, including, but not limited to, DNA/RNA sequences, compressed data, ...
The writer is unable to pursue snowboarding due to knee issues, but has come to accept and move on from the dream. They now focus on their current life and hobbies, finding satisfaction in the present moment.
J.C.R. Licklider proposed the concept of man-computer symbiosis in 1960, where humans and computers work together to solve complex problems, with the computer handling routine tasks and the human providing goals, hypotheses, and evaluations. To achieve this symbiosis, significant advancements in computer technology, including memory organization, programming languages, and input/output ...
Linear's speed comes from its local-first architecture, where the browser stores data and syncs with the server in the background. The app's design, including shortcuts and animations, also plays a crucial role in making it feel fast and responsive.
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The /lost+found/ folder in Linux and Unix is for storing files that fsck, the filesystem check and repair command, recovers from a damaged filesystem. You would interact with it after a system crash or power failure, when fsck places recovered files there.
Weaker isolation levels in databases can lead to concurrency bugs and security vulnerabilities, as seen in cases like Flexcoin and Poloniex. Using serializable isolation as the default can prevent such issues.
Lathe is a tool that generates hands-on technical tutorials on demand using LLM skills, allowing users to learn by working through tutorials themselves. It's a combination of LLM skills and a Golang CLI used to store, manage, and view generated tutorials.
IOCCC29 had a high submission quality and similar volume to last year, possibly due to improved website design and social media presence. The contest's rules and guidelines were rewritten for this year, and the next contest, IOCCC30, is planned for late 2026.
A magnitude 7.8 earthquake struck the southern Philippines on June 8, 2026, causing damage and a tsunami warning in General Santos city. No casualties were reported but a small building collapsed and aftershocks followed.
IBM introduced the Electronic Calculating Punch, type 604, a programmable calculator that used vacuum tubes and was much smaller and cheaper than computers. It was highly successful, with over 5600 units produced, and led to the development of IBM's vacuum-tube computers in the 1950s.
The user, a 10-year experienced software engineer, is concerned that their domain expertise in finance and payment processing is becoming less valuable due to advancements in AI and LLMs, which can now perform tasks such as writing code and debugging. The user is worried about their long-term employability and is considering shifting their domain expertise to areas where LLMs are not yet ...
The user is frustrated with expensive Sennheiser wireless microphone battery packs and decided to replicate them using 3D printing and third-party cells. They successfully created a working battery pack.
San Diego State University installed 1,300 AI-enabled cameras on campus, with over 330 pointing at student housing. The school claims to only use basic motion detection, but the cameras' capabilities include facial recognition and license plate reading.
The user's AI development process involves automated doubt from multiple perspectives to ensure quality, using subagents to critique and audit artifacts. This process originated from a lack of trust and has developed into a trust signal, requiring patience, practice, and expertise to terminate the loop.
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2026-06-07 17:21:57 UTC
ycombinator.com
Llama
Proliferate is building an operating system for modern engineering, automating software development to make engineering more human. They're hiring an engineering lead to build the core product with high ownership and a top-market salary.
Each digit represents a different colour channel: red, green, and then blue. the restriction has made me more open to errors and it's totally fine. 900 has full red channel (9) and nothing in green (0) or blue (0). so in my theme, 00 is... off-black. so you can just use lookup table if you want. click here to download the theme - it's free to use and works