Semaglutide linked to lower predicted dementia risk

Cultivating a state of mind where new ideas are born (2023)

https://substackcdn.com/image/fetch/$s_!9VgW!,w_2400,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4697c31d-2502-48d2-b6c1-11e5ea97536f_2560x2174.jpeg
The author discusses the importance of solitude and isolation for creative individuals, citing examples from mathematician Alexander Grothendieck and filmmaker Ingmar Bergman. They argue that this state allows for a heightened sensitivity to new ideas and a freedom from social pressure.

AI in drug discovery – what it is, where we stand and the path forward

At-home test for infected ticks could improve Lyme Disease diagnosis

https://th-thumbnailer.cdn-si-edu.com/Y09atCGdOXPq5O4siAbvEpY7gFE=/1026x684/filters:focal(1061x707:1062x708)/https://tf-cmsv2-smithsonianmag-media.s3.amazonaws.com/filer_public/44/ad/44ad8f8b-e8c6-4c3b-9d22-10eececf06c3/gettyimages-1602304607.jpg
The US experiences a significant number of tick-borne illnesses, with over 31 million Americans affected annually. Lyme disease is the most common diagnosis, with an estimated 476,000 patients treated each year.

Abdominal fat predicts heart disease risk better than BMI

https://www.acc.org/-/media/9E7FA8BE7B44449AB9993CC9237EF455.png
A study published in JACC found that waist circumference and waist-to-hip ratio are better indicators of cardiovascular disease risk than body mass index (BMI) alone. Adding these measures to BMI can reclassify individuals with normal weight as high-risk for heart disease.

Asus Bike Booster

https://dlcdnwebimgs.asus.com/gain/36fca81d-66d4-4a3a-9fa3-05976be35494/w800
Follow the user manual for safe and proper use of the ASUS Oxiis E250G1. Failure to comply with instructions may result in damage to the product or others, and voids warranty.

RISC-V: They Should Have Known Better

https://dmitry.gr/images/rv-BatLight.jpg
RISC-V's design is flawed due to its excessive optionality, leading to a lack of coherence and consistency across the architecture. This makes it difficult for developers to write code that works on all RISC-V cores, resulting in fragmentation and wasted time debugging issues.

Super El Niño Keeps Growing as New Forecasts Reach Record Territory Ahead Winter

https://www.severe-weather.eu/wp-content/gallery/long-range/el-nino-ocean-surface-temperature-anomaly-pacific-north-america-atmospheric-weather-bridge-united-states-canada-walker-cell-schematic-record-event-2026.jpg
A Super El Niño event is rapidly strengthening across the tropical Pacific, with record-level westerly wind anomalies and subsurface ocean heat driving its growth. The latest forecasts indicate a historic peak in late 2026/early 2027, with significant impacts on global weather patterns expected.

Auto-research with codex: How I achieved a 232x Faster Kernel

https://bear-images.sfo2.cdn.digitaloceanspaces.com/sankalp/codex-image-1.webp
The author participated in a GPU Mode contest to implement batched square compact-Householder QR factorization, achieving a 232x speedup over the baseline solution. They used blocked Householder and WY updates to optimize performance on NVIDIA B200 GPUs.

AI has access to a vastly larger working memory than the human brain

https://substackcdn.com/image/fetch/$s_!DIxw!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2e2e14e7-c536-49c0-9f27-79b1073dd527_1279x759.jpeg
AI systems excel in mathematics due to their ability to process and store vast amounts of information, whereas humans are limited by working memory capacity. This allows AI models to generate longer chains of deductions and explore multiple possibilities more efficiently than humans can.

A fortuitous decade as an indie software developer

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Tracking down a Zsh history data loss bug

The author investigated a bug in Zsh where commands were sometimes missing from the shell history file, despite being run previously. The issue was eventually tracked down to an incorrect implementation of signal handling in savehistfile, which caused it to truncate the history file when interrupted by a signal.

Tea5767-Radio-Tuner

https://private-user-images.githubusercontent.com/289482152/607533571-b35eaf25-04c4-40bf-98c2-4cec20e6fc4c.jpeg?jwt=eyJ0eXAiOiJKV1QiLCJhbGciOiJIUzI1NiJ9.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.pZPc4bEcp4VP5cWnumvg3bhg9Y7DPqsdZiREHAjRflw
An ESP32-based FM radio uses a TEA5767 tuner, PAM8403 amplifier, OLED display, and KY-040 encoder. The project includes a custom PCB design with improvements over the breadboard prototype.

ChatGPT lost 22 points of web share in a year

https://aicharts.grok.me/charts/market-share.png
Worldwide AI-chatbot web visits: ChatGPT 76% → 54%. Gemini 6% → 28%. Claude 1% → 9%. This is not monthly users and not revenue. Similarweb worldwide web-visit share (desktop + mobile web). May 2026 is still the latest comparable stacked print as of 12 Aug (Momentic / Similarweb). Gemini’s 1B app MAU can coexist with ~28% web share because so much Gemini use is in-app / Android.

A spectre is haunting Unicode

https://www.dampfkraft.com/by-id/a824aa10/img/ghostcanvas.l.jpg
The JIS X 0208 encoding was established in 1978 with added characters that later became known as ghost characters, which had no obvious sources. An investigation in 1997 discovered the origins of most ghost characters, including some being mistakes during cataloging and others having unclear or misread sources.

SugarTrack – an offline Android logbook for blood sugar (no account, no cloud)

https://sugartrack-beta.vercel.app/icon.png
This app, SugarTrack, is a personal blood sugar tracking logbook that stores data locally on the phone without requiring a login or cloud backup. It allows users to log readings and export them as PDF or CSV files for sharing with doctors.

Credit card debt rises to $1.26T, nearing all-time record

https://cdn.abcotvs.com/dip/images/19668113_081226-wpvi-credit-card-debt-10a-video--vid.jpg
US credit card debt reached $1.26 trillion, surpassing the previous record of $1.28 trillion, with outstanding balances increasing by $21 billion in Q2. Delinquency rates rose to 12.8% from mid-2022 due to old debts rather than new charges.

Bede Liu, a digital signal processing pioneer, has died

https://spectrum.ieee.org/media-library/portrait-of-an-elderly-asian-man-softly-smiling-in-a-suit-jacket-and-tie.jpg?id=67609508&width=1200&height=750
H. Vincent Liu was a renowned electrical engineer who pioneered digital signal processing, enabling technologies like streaming video and cellphone calls. He received numerous awards for his contributions to the field, including the 2018 IEEE Jack S. Kilby Signal Processing Medal.

Tess's Android Wayland Compositor

https://opengraph.githubassets.com/65e20efecc799d497af1317103fa8e06af53a1c7fd015c5913040f05e85ea0ca/wmww/tawc
tawc is a rootless Android app that runs Linux CLI and graphical programs, using its own Wayland compositor and tawcroot for emulation. The project has limitations, including no real sandboxing, desktop GL support, or x86 builds.

Working with AI feels more like leadership than coding

The author reflects on the shift from treating AI like a compiler to collaborating with it, recognizing that good leaders share context and explain desired outcomes. Effective use of AI requires expressing intent beyond just giving instructions.

Voltair (YC W26) Is Hiring a Test Flight Engineer

https://bookface-images.s3.amazonaws.com/small_logos/a981c3ee0de6ecf9a915e188b211780fce335e44.png
Voltair is building a distributed drone network for earth observation, focusing on power utilities. They're seeking a Flight Test Engineer to validate test fixtures and deploy drones for customer contracts within 90 days of arrival.

Jaithon 3, a fast programming language with the perfect syntax

https://opengraph.githubassets.com/095743e182348931ee276df1635968489de52061641dfb401e8d4ba358758bf4/abhiramasonny/jaithon
Jaithon is a dynamically executed and garbage collected language with a bytecode VM, combining elements from Java, Rust, and Python. It uses AI-generated documentation to speed up development but emphasizes human review for accuracy.

Humazon

https://hughhowey.com/wp-content/themes/hughhowey2023new/assets/images/HH-circle.png
The author discusses the rise of AI-written books and content farms, questioning whether readers should be judged for consuming such works. They advocate for a bookstore experience where authors are fully vetted, allowing readers to support human writers.

I Remain a Skeptic

https://blog.jsbarretto.com/static/img/profile.jpg
The author questions the effectiveness of Large Language Models (LLMs) in software development, citing a lack of evidence for improved quality, speed, or security. They argue that industry hype and noise have overshadowed actual productivity gains from using LLMs.

Show HN: Eigendrum - Draw any shape and hear what it sounds like as a drum

https://eigendrum.com/docs/hero.png
Eigendrum is a software that solves the eigenvalue problem for drum shapes, allowing users to create and play custom drums. It uses numerical methods to find the frequencies of standing waves within a given shape.

The Wow signal was a strong narrowband radio signal detected on August 15, 1977

https://upload.wikimedia.org/wikipedia/commons/thumb/d/d3/Wow_signal.jpg/330px-Wow_signal.jpg?utm_source=en.wikipedia.org&utm_campaign=parser&utm_content=thumbnail
The Wow! signal was a strong, narrowband radio signal detected in 1977 by Ohio State University's Big Ear radio telescope, sparking interest in the search for extraterrestrial intelligence. Despite numerous follow-up searches and hypotheses, the signal has never recurred or been confirmed as of 2024.

Pizza Box Project Stack

https://cblgh.org/media/cut-box.jpg
The author created a paper-based project tracker inspired by Ratfactor's idea, using three stacks: blanks, tasks, and finished. They found it helpful for offloading mental tasks and retaining autonomy while keeping use-friction low.

The mathematical beauty of hyperbezier curves

https://linebender.org/blog/hyperbezier/log_aesthetic_evolutes.svg
A new curve family, the hyperbezier, is proposed as a potential successor to cubic Béziers in 2D vector graphic design. The hyperbezier has smoother curvature variation and can represent higher-tension regions with large curvature peaks.

Modeling and Verification of Keeta's Consensus [pdf]

Keeta's two-phase consensus algorithm preserves agreement under a fixed, equally weighted set of representatives and generalizes to any number of representatives. However, a contended account can be driven into a permanent lockout due to client contention. The model checks safety as an invariant over bounded configurations but does not establish liveness.

2D Gaussian Splatting for Bézier Spline Line Art Vectorization

A new state-of-the-art method for line art vectorization is introduced using recent advances in depth prediction and semantic feature extraction models. The proposed approach achieves high-quality results that align with artistic intent, while being fast and compatible with user input.