Why has there been so little progress on Alzheimer's disease?

USB Cheat Sheet (2022)

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A USB cheat sheet was created to clarify USB terms and save time. It covers USB versions, lane striping and bonding, and wire configurations for different USB speeds.

The Free Universal Construction Kit

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The Free Universal Construction Kit is a set of adapters that allows children's construction toys to work together, promoting creative play and hybrid designs. The Kit is a grassroots remedy for proprietary toy systems, available for free download and 3D printing.

Flickr: The first and last great photo platform

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Flickr remains a unique online community for photography enthusiasts, offering robust features and a sanctuary from algorithm-driven content. Its Pro subscription provides benefits like unlimited storage, ad-free galleries, and exclusive savings, justifying the cost for many users.

1-Bit Hokusai's "The Great Wave" (2023)

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User is recreating Hokusai's 36 views of Mount Fuji as 1-bit pixel art on old Macintosh computers for nostalgia and flow state. They use Aldus SuperPaint 3.0 on Quadra 700 or PowerBook 100 to create authentic 512x342 pixel images.

OpenAI Privacy Filter

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OpenAI releases Privacy Filter, a small model for detecting and redacting PII in text, designed for high-throughput privacy workflows and context-aware detection. It achieves state-of-the-art performance on the PII-Masking-300k benchmark and can be fine-tuned for different data distributions and privacy policies.

Using coding assistance tools to revive projects you never were going to finish

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The user tested Claude Code with a personal project, a shim between YouTube Music and OpenSubsonic API, and found it helpful in implementing the project from scratch. The user was able to get a working service in a short evening, but still has concerns about relying too much on AI coding assist and losing skills.

America's Geothermal Breakthrough

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The US geothermal energy sector is expanding with support from the government and innovations in enhanced geothermal technologies. Companies like Fervo Energy are leading the way with new projects and technologies to access geothermal resources.

The Joy of Folding Bikes

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I recently started using a folding bike, a Brompton, which has greatly improved my commuting experience. It's convenient, durable, and cost-effective, paying for itself in just 28 weeks.

Math Is Hard – OpenBSD Stories

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The VAX architecture had a simple exception model with traps and faults, but the kernel had to skip the instruction in case of a fault to prevent a signal loop, which was not possible due to the hardware design. A fix was implemented in 2002 to add a skip_opcode function to compute the address of the next opcode, effectively skipping the offending instruction, and it was later carried over to OpenBSD.

Her Life Savings Mysteriously Disappeared After a Systems Glitch

Fidelity Investments deleted a physician assistant's financial accounts and history after a systems update, leaving her with no explanation or apology. The woman, Ms. Gruntmane, lost tens of thousands of dollars in accounts, including a retirement fund set up by her father.

Optimizing Datalog for the GPU

New 10 GbE USB adapters are cooler, smaller, cheaper

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A new 10G USB 3.2 adapter from WisdPi offers a compact alternative to bulky Thunderbolt adapters, but its performance depends on the USB port's bandwidth. It reaches full 10 Gbps speed only with a USB 3.2 Gen 2 2x2 port, otherwise it's slower.

Simulacrum of Knowledge Work

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Report quality is often judged by superficial measures like writing style, not actual content. This can lead to reliance on AI-generated work, where appearance of quality is prioritized over actual value.

How Hard Is It to Open a File?

Passing file paths to privileged processes can lead to security vulnerabilities due to TOCTOU (time-of-check to time-of-use) races and symlink attacks. Using file descriptors instead of paths is a safer approach, and libraries like libglnx provide fd-based filesystem operations to help mitigate these issues.

The Long Reply

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Welcome! If you’re new here, please consider signing up for this free newsletter to get more random weird cultural stuff in your Inbox! A couple weeks ago, a post of mine went unexpectedly viral on Threads. As of this writing, it has been viewed 2,380,872 times. This is what I wrote: I did not expect it to be any more popular than any other silly thing I might post on Threads. But for some ...

Mine, an IDE for Coalton and Common Lisp

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mine is an IDE for Coalton and Common Lisp on Windows, macOS, and Linux. It offers a complete, all-in-one application and a command-line variant with integrated REPL, debugger, and structural editing.

What async promised and what it delivered

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The evolution of concurrency abstractions, from threads to callbacks to promises to async/await, has improved the local experience of writing async code but introduced new costs and complexities at the global level, such as function coloring and ecosystem fragmentation. Each solution solved a problem but introduced new structural costs, and language designers are now reevaluating the approach ...

Desmond Morris has died

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Desmond Morris was a zoologist and surrealist painter who wrote The Naked Ape, a book that framed modern humans as ape-like despite technological advances. He popularised science through his books and TV shows, including The Human Animal, which explored human customs and their biological roots.

Martin Galway's music source files from 1980's Commodore 64 games

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The user is sharing music player information from the 1980s, specifically from games like Wizball and Athena, and is allowing others to use and modify the work. The user acquired the rights to the music and code from Infogrames and credits the original author, Martin Galway.

GPT‑5.5 Bio Bug Bounty

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OpenAI introduces Bio Bug Bounty for GPT-5.5, inviting researchers to find a universal jailbreak for bio safety questions. Applications open April 23, 2026, and close June 22, 2026.

Show HN: Kloak, A secret manager that keeps K8s workload away from secrets

Kloak replaces secrets at the network edge, eliminating accidental exposure and misuse. It's open source, kernel-level, and works with any language or framework without an SDK.

Discret 11, the French TV encryption of the 80s

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Canal+, a French TV channel, used a simple encryption system called Discret 11 to block unauthorized viewing, but it was eventually cracked and pirated due to its simplicity and the leak of its schematics. The system was later replaced with Nagravision encryption in 1992 and retired by 1995, but Canal+ went on to become a major satellite broadcaster in Europe.

Lute: A Standalone Runtime for Luau

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Lute provides a standalone runtime for Luau with built-in APIs for common tasks. It allows for general-purpose programming outside of game engines, similar to Node.js or Deno.

Colorado Adds Open-Source Exemption to Age-Verification Bill

The amended CO SB51 bill passed in the house committee with a strong exemption for open source software. It excludes operating system providers that distribute software under open source license terms.

Can you stop beans from making you gassy?

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Agents Aren't Coworkers, Embed Them in Your Software

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Agentic management software is gaining popularity with tools like ZeroClaw and AutoGPT, allowing for generic agent loops that help with tasks. Agents can be made less noisy and more effective by integrating with existing software using patterns like CLI interfaces and reconciliation loops.

Which one is more important: more parameters or more computation? (2021)

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Researchers propose two new methods to study the relationship between model size and computation in deep learning. They show that increasing model size or computation can improve performance without increasing the other.

A web-based RDP client built with Go WebAssembly and grdp

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A web-based RDP client connects to Windows Remote Desktop servers directly from browsers without plugins. It uses a Go proxy server to bridge WebSocket connections to the RDP server's TCP port.

Insights into firewood use by early Middle Pleistocene hominins

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