Researchers at UC Berkeley and UC San Francisco have developed a CRISPR-based approach to selectively destroy cancer cells with a specific mutation in the p53 tumor suppressor gene. This method, called RNA-triggered chromatin shredding, can target "undruggable" cancers and potentially open up new targets for cancer therapy.
Apple rewrote the TrueType hinting interpreter from C to memory-safe Swift to improve security and performance, achieving a 13% speed increase and exact compatibility with the C implementation. The Swift interpreter's design and optimizations, such as using noncopyable structures and Span, demonstrate the language's ability to balance safety, ergonomics, and performance, making it suitable ...
User upgraded Gemma 4 to MTP, achieving 72.2 tokens/second on an Apple M1 Max. MTP draft model improved performance by 24% with optimal settings found to be 3 draft tokens.
Malware developers added nuclear and biological text to spyware to evade AI security scanners. This highlights the need for balance between safety and functionality in AI models.
The House passed H.R. 6028, a bill that would change the US Copyright Office's structure and make it more political. The bill would transfer power from the Library of Congress to the Register of Copyrights, a presidential appointee.
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A proposal to precompute a document's KV cache and let agents reuse it is shown to be 49.7x cheaper in compute than re-prefilling. This results in a potential savings of millions of dollars per popular document, with the main challenge being lossless KV compression and cross-party payment.
TLDR: depthfirstβs production autonomous security agent discovered 21 zero-day vulnerabilities in FFmpeg, after intensive security analysis by Google and Anthropic. Moving beyond theoretical analysis, our agent produces concrete, reproducible PoC inputs to confirm its findings at a fraction of the costs ($1k vs. $10k). Several of the findings had been sitting latent for 15 to 20 years. We ...
User trying to generate decent-looking programs with AI, found a "Qt style" trick that works for them, and wants feedback on its effectiveness and potential for other styles. They've successfully translated personal software to "Qt style" with AI tools like Codex.
A historical pioneer in the complex technology of electric motors without magnets, i.e. with no rare earths, Renault Group is continuing to set itself apart on a market where 90% of electric cars have motors with magnets. Discover the range of electric motors by Renault Group. Requiring no piston or cylinders, an electric car motor converts electrical energy from the battery into mechanical ...
Log in to a shared online world where characters live and interact in real-time. The game features instant single-player mode and customizable controls for movement and abilities.
Generate dashboards and analysis in BitBoard using AI chat or coding agents to create connected assets. Store connections, queries, and code for reproducible analysis and collaborate with teams in the browser.
A freelance translator in Ottawa prioritizes work over gym classes due to tight deadlines. She explains to a Director General that AI translation tools like ChatGPT are not a replacement for human translators, requiring constant coaching and double-checking.
The user successfully booted a UEFI HTTP(S) setup using Qemu and OVMF, but encountered issues with certificate validation due to a security level mismatch. The problem was resolved by either upgrading the server's TLS certificate or patching the OVMF firmware to match the default security level.
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A PDF can store both visual and structured data. By using a specific property in the PDF spec, a document can be created that renders visually the same but extracts clean markdown text when read by machines.
Scientists have found that Earth's water may not have come from comets or asteroids, but rather from the planet's own processes. A new theory suggests that Earth's magma ocean and hydrogen-rich atmosphere could have combined to produce water.
A free, offline-first stargazing web app β the live sky from where you stand, from naked-eye views down to a telescope eyepiece.
Pan and zoom a procedurally generated infinite landscape. Every name becomes a tree.
The author discusses the concept of "life before main" in Rust, where initialization happens before the main function is called, and explains how to use linker sections to register data and perform initialization in a single-threaded, highly-consistent environment. Linker sections allow for arbitrary aggregation and co-location of related data across the binary, and can be used to avoid ...
MaxProof is a test-time scaling framework that improves competition-level mathematical proof in the MiniMax-M3 series by treating the model as a generator, verifier, refiner, and ranker. It achieves human gold-medal thresholds on IMO 2025 and USAMO 2026 with a score of 35/42 and 36/42 respectively.
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2026-06-12 13:52:57 UTC
ycombinator.com
Llama
Hazel is hiring a full stack engineer to deploy and scale AI for government procurement, requiring a TS/SCI clearance and experience with AWS, Python, and React. The role involves architecting and building Hazel's platform, working with customers, and delivering innovative solutions in a classified environment.
Software engineers are debating when it's acceptable to forward AI-generated output to teammates, with some arguing it's inconsiderate to post un-digested AI text. Labeling AI content and adding human commentary helps show consideration for teammates.
The user is concerned about the increasing number of contributions to their open source projects made with Large Language Models (LLMs), which they see as a threat to human involvement and interaction. They have implemented a new policy where they only accept contributions from real people, and reject those generated solely by LLMs, to maintain a more human-centered approach to coding.
A man named Charles Lounsberry wrote a beautiful will while in a lunatic asylum, leaving children the outdoors, lovers their imaginary world, and adults memories and poetry. His will was published in "The Doonion" and admired for its kindness and beauty.
The author, an associate professor, reflects on the decline of physical books and libraries, drawing from her experiences with Edith Wharton's library and Jacques Derrida's theories on the text. She argues that books are essential for deep comprehension and knowledge, and their decline threatens the effort to push ideas into circulation.
StackScope analyses the tech stacks of new product launches. See what frameworks, hosting, analytics and tools sites use. Detect AI-built sites. Track technology trends.
WASI 0.3 is now official, featuring native async support in WebAssembly Components. This simplifies async operations and enables better composability among components.
Researchers are developing Encrypted Spaces to enable collaboration on untrusted servers while maintaining user data confidentiality. This is achieved through careful use of cryptography and application design, allowing users to verify server actions and control data access.