The First At-Home Test for Infected Ticks Could Improve Lyme Disease Diagnosis

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The US experiences a significant number of tick-borne illnesses, with over 31 million Americans affected annually. Lyme disease is the most common diagnosis, with an estimated 476,000 patients treated each year.

AI Can Now Design Functional Viruses. Should We Worry?

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Researchers at Stanford University designed 16 functional viruses from scratch using a genomic language model, which can potentially combat bacterial infections. The AI-designed phages were able to infect E. coli strains that had evolved resistance to natural viruses.

Auto-research with codex: How I achieved a 232x Faster Kernel

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The author participated in a GPU Mode contest to implement batched square compact-Householder QR factorization, achieving a 232x speedup over the baseline solution. They used blocked Householder and WY updates to optimize performance on NVIDIA B200 GPUs.

The AI Situation in Software Development

You need to spend time designing and explaining your project's goals, issues, and blueprint to AI models, as they can't follow detailed specs or large documents. Effective implementation requires refining the approach through feedback loops and improving signal-to-noise ratio in the codebase.

Yadda 3.0.0: BDD in the Age of AI Agents

Yadda 3 is a Node-only BDD library for JavaScript that maps ordinary language specifications to executable code, with significant updates and improvements. The new version features modernized source code, TypeScript definitions, and support for writing feature specifications in GitHub-flavoured Markdown.

The other Sean Byrne doesn't exist

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The author's name was incorrectly matched to a U.S. government restricted-party list, causing him to be denied access to the App Store Connect and other services. The match appears to be due to a fabricated identity used by an Irish aircraft-parts company in 2009.

RISC-V: They Should Have Known Better

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RISC-V's design is flawed due to its excessive optionality, leading to a lack of coherence and consistency across the architecture. This makes it difficult for developers to write code that works on all RISC-V cores, resulting in fragmentation and wasted time debugging issues.

The mathematical beauty of hyperbezier curves

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A new curve family, the hyperbezier, is proposed as a potential successor to cubic Béziers in 2D vector graphic design. The hyperbezier has smoother curvature variation and can represent higher-tension regions with large curvature peaks.

Show HN: Quasicrystals Animation Playground with WebXR

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Show HN: Eigendrum - Draw any shape and hear what it sounds like as a drum

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Eigendrum is a software that solves the eigenvalue problem for drum shapes, allowing users to create and play custom drums. It uses numerical methods to find the frequencies of standing waves within a given shape.

The Color of White Light

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The author discusses the limitations of color representation in photography and daily life, where light sources can have varying spectral distributions. They built a simple spectrograph to analyze different light sources, including LEDs and incandescent bulbs.

2D Gaussian Splatting for Bézier Spline Line Art Vectorization

T3X/0 a Minimal Procedural Language

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T3X/0 is a small, portable programming language with Pascal-like syntax and BCPL-inspired semantics. It comes with editors and compilers for various platforms, including CP/M and DOS.

Going Dark, and the era of law enforcement hacking

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The author is concerned that AI advancements will make software too secure, potentially rendering US intelligence and law enforcement agencies unable to access encrypted data. This could lead to a "dark" era for these agencies, as they struggle to find vulnerabilities in highly secured systems.

Could a computer scientist build a brain?

A computer scientist attempts to write a program that can generate the wiring diagram of a brain, given its genome. The program must be small enough to fit in the genome and run within a developmental time window of about 1 year. The algorithm must scale for different numbers of neurons across various species, from C. elegans to humans.

The Problem

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The world's leading AI companies aim to build general AI that can do anything humans can, but experts warn this could lead to an unprecedented catastrophe. The development of superintelligent AI poses a significant existential risk due to its potential for goal-oriented behavior and the lack of understanding about how it works.

Xorshift Generators

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Using GCC's Nested Functions with Wide Pointers and No Trampolines II

GCC now guarantees that nested functions not accessing parent variables don't require trampolines, making it safer. The compiler can also automatically transform code into a form without trampolines using built-in functions and macros.

In 1962, Egypt's Missile Program Lost Its Key Scientist Without a Trace

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Egypt's pursuit of Nazi rocket scientists led to the disappearance of Heinz Krug, a key player in their program. Krug vanished on September 11, 1962, after being targeted by Mossad agents and possibly assassinated.

Möbius Strips and Differential Equations

The article discusses algebraic topology and its importance in modern mathematics. It explores the properties of a Möbius strip, which has only one side, and how this property relates to differential equations. The author uses a power series method to solve a differential equation centered at different points on the complex plane, creating multiple solutions that agree locally but not ...

Working with AI Feels More Like Leadership Than Coding

The author reflects on the shift from treating AI like a compiler to collaborating with it, recognizing that good leaders share context and explain desired outcomes. Effective use of AI requires expressing intent beyond just giving instructions.

A Planet Position Widget

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The author created a Mac widget using TerminalWidget and Astropy to track planetary positions, displaying azimuth and altitude. It runs every 30 minutes via launchd, showing celestial bodies' locations even when visibility is obscured.

Brazilian election filter in X For You timeline

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Qwen 3.8 27B

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This repository provides FP8-quantized model weights and configuration files for the post-trained Qwen3.8-27B model, offering managed inference without infrastructure maintenance through the Qwen Cloud service. The model supports various tasks, including vision-language understanding, agent execution, and long-horizon agentic tasks.

Google is making private AI practical with homomorphic encryption

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Google's HEIR compiler toolchain enables secure private AI inference using homomorphic encryption, balancing privacy and security. The open-source tool converts pre-trained models to operate on encrypted inputs, making it a one-click solution for non-experts.

Firefox is now the last major browser that still supports uBlock Origin

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Firefox supports uBlock Origin despite Microsoft Edge's Manifest V3 transition, which may block ad-blocking extensions. This makes Firefox the only major browser without compromises for die-hard uBlock Origin fans.

388 years ago, Galileo worked out why human giants can't exist

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Show HN: ThoughtDAG – An editable context graph for LLM conversations

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One: record the database version. Two: use independent reviewers. Three: resolve conflicts with a third reviewer. Answer updated in place No hidden memory selector. What the model sees, why, and what was removed stay visible in the graph. Visible Editable Inspectable

Brain turns listening inward during REM sleep, EEG recordings suggest

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RustDesk now supports true unattended remote access on Wayland

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RustDesk now offers unattended access on Wayland without approval, supporting multi-monitor setups. A preview build is available for x86_64 Debian/Ubuntu-based systems to test and provide feedback.