Semaglutide linked to 26% lower 5-year predicted dementia risk

AI Isn't Outthinking Mathematicians. It's Out-Remembering Them

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AI systems excel in mathematics due to their ability to process and store vast amounts of information, whereas humans are limited by working memory capacity. This allows AI models to generate longer chains of deductions and explore multiple possibilities more efficiently than humans can.

So How Is AI Drug Discovery Doing, Really?

The First At-Home Test for Infected Ticks Could Improve Lyme Disease Diagnosis

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The US experiences a significant number of tick-borne illnesses, with over 31 million Americans affected annually. Lyme disease is the most common diagnosis, with an estimated 476,000 patients treated each year.

Auto-research with codex: How I achieved a 232x Faster Kernel

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The author participated in a GPU Mode contest to implement batched square compact-Householder QR factorization, achieving a 232x speedup over the baseline solution. They used blocked Householder and WY updates to optimize performance on NVIDIA B200 GPUs.

First human trials of designer protein therapies stun US neuroscientists

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Chinese researchers are testing DREADDs, a gene therapy to reduce neuronal activity, in clinical trials for epilepsy, Parkinson's disease and neuropathic pain. The technology developed by Bryan Roth could offer a more precise treatment with reduced side effects compared to other approaches.

RISC-V: They Should Have Known Better

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RISC-V's design is flawed due to its excessive optionality, leading to a lack of coherence and consistency across the architecture. This makes it difficult for developers to write code that works on all RISC-V cores, resulting in fragmentation and wasted time debugging issues.

A Spectre Is Haunting Unicode

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The JIS X 0208 encoding was established in 1978 with added characters that later became known as ghost characters, which had no obvious sources. An investigation in 1997 discovered the origins of most ghost characters, including some being mistakes during cataloging and others having unclear or misread sources.

Working with AI Feels More Like Leadership Than Coding

The author reflects on the shift from treating AI like a compiler to collaborating with it, recognizing that good leaders share context and explain desired outcomes. Effective use of AI requires expressing intent beyond just giving instructions.

Voltair (YC W26) Is Hiring a Test Flight Engineer

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Voltair is building a distributed drone network for earth observation, focusing on power utilities. They're seeking a Flight Test Engineer to validate test fixtures and deploy drones for customer contracts within 90 days of arrival.

Could a computer scientist build a brain?

A computer scientist attempts to write a program that can generate the wiring diagram of a brain, given its genome. The program must be small enough to fit in the genome and run within a developmental time window of about 1 year. The algorithm must scale for different numbers of neurons across various species, from C. elegans to humans.

2D Gaussian Splatting for Bézier Spline Line Art Vectorization

A new state-of-the-art method for line art vectorization is introduced using recent advances in depth prediction and semantic feature extraction models. The proposed approach achieves high-quality results that align with artistic intent, while being fast and compatible with user input.

A controversial Alzheimer's surgery is said to reverse symptoms

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A Chinese doctor performed a surgery called deep cervical lymphatic-venous anastomosis (dcLVA) to treat Alzheimer's disease, with promising results. The procedure involves connecting tiny lymphatic vessels in the neck to nearby veins, potentially improving brain drainage and clearing waste proteins.

The mathematical beauty of hyperbezier curves

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A new curve family, the hyperbezier, is proposed as a potential successor to cubic Béziers in 2D vector graphic design. The hyperbezier has smoother curvature variation and can represent higher-tension regions with large curvature peaks.

Show HN: Eigendrum - Draw any shape and hear what it sounds like as a drum

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Eigendrum is a software that solves the eigenvalue problem for drum shapes, allowing users to create and play custom drums. It uses numerical methods to find the frequencies of standing waves within a given shape.

BriskDB

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BriskDB is an alpha SQLite fork that adds parallel writes, PostgreSQL compatibility, and embedded Rust/Python APIs to ordinary SQLite files. It provides a responsive read-only data browser and supports various protocols like HTTP, PostgreSQL, MySQL, and MongoDB.

The other Sean Byrne doesn't exist

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The author's name was incorrectly matched to a U.S. government restricted-party list, causing him to be denied access to the App Store Connect and other services. The match appears to be due to a fabricated identity used by an Irish aircraft-parts company in 2009.

The Dutch Community Where People Live on Strips of Land in a Lake

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Residents in Loosdrecht, Netherlands live on manmade islands within a lake created by peat mining. These homes were built on leftover strips of land after peat was unloaded and dried.

Printytron – Type it. 3D Print it

Going Dark, and the era of law enforcement hacking

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The author is concerned that AI advancements will make software too secure, potentially rendering US intelligence and law enforcement agencies unable to access encrypted data. This could lead to a "dark" era for these agencies, as they struggle to find vulnerabilities in highly secured systems.

Pizza Box Project Stack

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One of the people who writes for an internet audience and whom I really enjoy reading is Ratfactor. I find that Ratfactor has a generally great attitude towards things. On his site he does lovely, lovely deep dives into personal projects of high personal importance and is generally fantastic at putting in the effort to document what he does, why he does it, and how he thinks about it. If ...

Yadda 3.0.0: BDD in the Age of AI Agents

Yadda 3 is a Node-only BDD library for JavaScript that maps ordinary language specifications to executable code, with significant updates and improvements. The new version features modernized source code, TypeScript definitions, and support for writing feature specifications in GitHub-flavoured Markdown.

The Color of White Light

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The author discusses the limitations of color representation in photography and daily life, where light sources can have varying spectral distributions. They built a simple spectrograph to analyze different light sources, including LEDs and incandescent bulbs.

Using GCC's Nested Functions with Wide Pointers and No Trampolines II

GCC now guarantees that nested functions not accessing parent variables don't require trampolines, making it safer. The compiler can also automatically transform code into a form without trampolines using built-in functions and macros.

In 1962, Egypt's Missile Program Lost Its Key Scientist Without a Trace

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Egypt's pursuit of Nazi rocket scientists led to the disappearance of Heinz Krug, a key player in their program. Krug vanished on September 11, 1962, after being targeted by Mossad agents and possibly assassinated.

Thunderbird's Desktop Calendar Visual Redesign

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The Thunderbird design team is redesigning the calendar portion of the application to modernize and streamline its functionality, aiming for a more user-friendly experience. The new design will be released gradually, with feedback from users helping shape future iterations.

Möbius Strips and Differential Equations

The article discusses algebraic topology and its importance in modern mathematics. It explores the properties of a Möbius strip, which has only one side, and how this property relates to differential equations. The author uses a power series method to solve a differential equation centered at different points on the complex plane, creating multiple solutions that agree locally but not ...

Qwen 3.8 27B

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This repository provides FP8-quantized model weights and configuration files for the post-trained Qwen3.8-27B model, offering managed inference without infrastructure maintenance through the Qwen Cloud service. The model supports various tasks, including vision-language understanding, agent execution, and long-horizon agentic tasks.

Firefox is now the last major browser that still supports uBlock Origin

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Firefox supports uBlock Origin despite Microsoft Edge's Manifest V3 transition, which may block ad-blocking extensions. This makes Firefox the only major browser without compromises for die-hard uBlock Origin fans.

Robot Videos: Heavy Lift Cargo Drones, Grippers, More

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DARPA's Lift Challenge showcases bizarre heavy-lift drone designs and live streams of the event. NASA's SkyFall helicopters use flexible antennas to detect frozen water on Mars.